F112
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F112
Sigma
(+)-Fenfluramine hydrochloride
| Synonym: | Dexfenfluramine hydrochloride, (+)-N-Ethyl-α-methyl-m-[trifluoromethyl]phenethylamine hydrochloride |
| CAS Number: | 3239-45-0 |
| Linear Formula: | C12H16F3N · HCl |
| Molecular Weight: | 267.72 |
| EC Number: | 221-806-0 |
| MDL number: | MFCD00069276 |
| PubChem Substance ID: | 24894746 |
Description
| Other Notes | Active isomer |
| Biochem/physiol Actions | Neurotoxic on prolonged administration or at high dosage; releases serotonin from axon terminals by a nonexocytotic mechanism; anorectic. |
Properties
| drug control | USDEA Schedule IV |
Safety
| Personal Protective Equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Statements | 23/24/25 |
| Safety Statements | 22-36/37/39-45 |
| RIDADR | UN2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | SH6824000 |
References
| reference | Crunelli, et al., Effects of d- and l-fenfluramine on striatal homovanillic acid concentrations in rats after pharmacological manipulation of brain serotonin. Pharmacol. Res. Commun. 12, 215-223, (1980) Abstract |
| Scuvee-Moreau, et al., Influence of fenfluramine and norfenfluramine stereoisomers on the firing rate of central monoaminergic neurons in the rat. Eur. J. Pharmacol. 179, 211-215, (1990) Abstract |
